Subject: Basic medicine
Subject: Clinical medicine
Year: 2026
Type: Article
Type: PeerReviewed
Title: A lipidomics roadmap: from basic research to societal challenges
Author: Fedorova, Maria
Author: Bendt, Anne K.
Author: Bertrand-Michel, Justine
Author: Fiehn, Oliver
Author: Godzien, Joanna
Author: Goracci, Laura
Author: Gruber, Florian
Author: Guan, Xue Li
Author: Han, Xianlin
Author: Holčapek, Michal
Author: Kuligowski, Julia
Author: Meikle, Peter J.
Author: Nepachalovich, Palina
Author: O'Donnell, Valerie B.
Author: Orešič, Matej
Author: Penkov, Sider
Author: Petrović, Snježana
Author: Potapov, Anton
Author: Prabutzki, Patricia
Author: Righetti, Laura
Author: Ruskovska, Tatjana
Author: Shevchenko, Andrej
Author: Simons, Kai
Author: Spickett, Corinne
Author: Vvedenskaya, Olga
Author: Watts, Jennifer
Author: Wenk, Markus R.
Author: Witting, Michael
Author: Xia, Yu
Author: Yang, Baoru
Author: Domingues, Rosario
Abstract: Lipidomics, a rapidly evolving discipline at the interface of biology and analytical chemistry, seeks to comprehensively characterize the lipid composition of biological systems. Driven by advances in mass spectrometry, chromatography and computational analysis, lipidomics has enabled the high-resolution mapping of lipid networks and their functional dynamics across molecular, cellular and organismal scales. In biomedical research, lipidomics is emerging as a powerful platform for biomarker discovery, enabling early diagnosis, prognosis, and therapeutic monitoring of cancer, metabolic, and neurodegenerative diseases. The field is also reshaping drug discovery by uncovering lipid-mediated pathways, identifying novel therapeutic targets, and refining assessments of drug efficacy and safety. Beyond medicine, lipidomic analyses are redefining food and nutrition science by elucidating how dietary lipids influence metabolic health and disease risk. In parallel, environmental and ecological lipidomics are emerging as powerful frameworks for assessing ecosystem health, tracking the impact of pollutants and exploring the biological consequences of climate change. Such approaches are also informing the discovery of sustainable lipid resources and the development of novel biotechnological and agricultural innovations. With its rapidly expanding analytical repertoire and cross-disciplinary relevance, lipidomics is poised to make substantial contributions to both fundamental biology and applied science. This Perspective aims to synthesise the current state of the field, delineate major analytical and conceptual challenges, and outline future directions for translating lipidomic knowledge into tangible societal and environmental benefits.
Publisher: Springer Nature
Relation: https://eprints.ugd.edu.mk/38742/
Identifier: oai:eprints.ugd.edu.mk:38742
Identifier: https://eprints.ugd.edu.mk/38742/1/s41467-026-73797-4.pdfIdentifier: Fedorova, Maria and Bendt, Anne K. and Bertrand-Michel, Justine and Fiehn, Oliver and Godzien, Joanna and Goracci, Laura and Gruber, Florian and Guan, Xue Li and Han, Xianlin and Holčapek, Michal and Kuligowski, Julia and Meikle, Peter J. and Nepachalovich, Palina and O'Donnell, Valerie B. and Orešič, Matej and Penkov, Sider and Petrović, Snježana and Potapov, Anton and Prabutzki, Patricia and Righetti, Laura and Ruskovska, Tatjana and Shevchenko, Andrej and Simons, Kai and Spickett, Corinne and Vvedenskaya, Olga and Watts, Jennifer and Wenk, Markus R. and Witting, Michael and Xia, Yu and Yang, Baoru and Domingues, Rosario (2026) A lipidomics roadmap: from basic research to societal challenges. Nature Communications, 17 (1): 4778. ISSN 2041-1723
