Subject: Biological sciences
Subject: Computer and information sciences
Subject: Clinical medicine
Year: 2025
Type: Article
Type: PeerReviewed
Title: The State-of-the-Art Review on FSHR, LHCGR, AR, ESR1, and ESR2 Key Mutations and Their Impact on the Effectiveness of Infertility Therapies—What We Know So Far
Author: Hristov, Daniela
Author: Stojanov, Done
Abstract: Mutations in hormone receptors significantly influence infertility and the outcomes of assisted reproductive technologies (ART). This review explores the functional interplay among mutations in FSHR, LHCGR, AR, ESR1, and ESR2 hormone receptors and their combined effects on hormonal regulation, ovarian response, and implantation. Rather than analyzing receptor mutations in isolation, we explore how mutations in these genes interact within a complex hormonal signaling network, shaping reproductive outcomes. We detail the molecular mechanisms of receptor dysfunction, their associated clinical phenotypes, and the role of genetic screening in guiding personalized ART protocols. A comprehensive understanding of these interactions is crucial for optimizing treatment strategies, improving reproductive success, and advancing targeted therapeutic approaches in reproductive medicine.
Publisher: MDPI
Relation: https://eprints.ugd.edu.mk/36307/
Identifier: oai:eprints.ugd.edu.mk:36307
Identifier: https://eprints.ugd.edu.mk/36307/1/receptors-04-00016-with-cover.pdfIdentifier: Hristov, Daniela and Stojanov, Done (2025) The State-of-the-Art Review on FSHR, LHCGR, AR, ESR1, and ESR2 Key Mutations and Their Impact on the Effectiveness of Infertility Therapies—What We Know So Far. Receptors, 4 (3). ISSN 2813-2564
Identifier: https://doi.org/10.3390/receptors4030016
